POTENTIAL PHYTOMOLECULES FROM AYURVEDIC HERBS AS AN ADJUVANT TREATMENT FOR ESSENTIAL HYPERTENSION MANAGEMENT: AN IN SILICO ANALYSIS.

Abstract

Hypertension that is essential continues to be one of the greatest risk factors for cardiovascular morbidity and death across the world, and it frequently necessitates the use of pharmaceutical medication for an extended period of time. Nevertheless, the investigation of supplementary treatment options is required because of restrictions such as medication resistance, unpleasant side effects, and the load on the economy. With its holistic and plant-based pharmacopoeia, Ayurvedic medicine presents a viable path for the identification of bioactive molecules that may serve as adjuvants to current hypertension medications. This is because Ayurvedic medicine adheres to the principle of ayurveda. An in silico technique will be utilized in this research project with the purpose of identifying and assessing the possible antihypertensive properties of phytomolecules that are produced from certain Ayurvedic herbs. The selection of important herbs that have traditionally been utilized for the management of hypertension was accomplished via the utilization of a complete literature search and ethnopharmacological data. These herbs include Terminalia arjuna, Rauvolfia serpentina, Withania somnifera, Ocimum sanctum, and Tribulus terrestris. The pharmacokinetic characteristics (ADMET profile) and drug-likeness of the bioactive chemicals derived from these plants were investigated with the use of computational techniques. The angiotensin-converting enzyme (ACE), the angiotensin II type 1 receptor (AT1R), and the endothelial nitric oxide synthase (eNOS) were the targets of molecular docking experiments that were carried out against important hypertension-related targets. The presence of substantial binding affinities and good interaction patterns with these targets was established by a number of phytoconstituents, which is indicative of the potential therapeutic effectiveness of these compounds. According to the findings of the study, several phytomolecules used in Ayurvedic medicine have the potential to act as effective adjuvant medicines in the treatment of essential hypertension by altering relevant regulatory pathways. In light of these findings, more in vitro and in vivo validation is required to validate the pharmacological efficacy and safety of the compounds. In the management of hypertension, the combination of in silico analysis with conventional knowledge offers the potential to produce therapies that are both cost-effective and reduce the adverse effects of the treatment.